Earl Clark had 19 points and nine rebounds, leading Louisville to one of the most lopsided routs in regional round history, 103-64 over Arizona on Friday night.
Louisville (31-5) played like the top seed in the NCAA tournament, topping 100 points for the first time this season and moving into the Midwest final. It was the Cardinals' most one-sided win ever in the tournament.
Twelfth-seeded Arizona (21-14) was led by Chase Budinger with 22 points.
Louisville built a 21-point halftime lead and eliminated any comeback hopes by opening the second half on an 18-5 run that made it 67-33.
The Cardinals just missed cracking the top five for most lopsided victories in regional history. UCLA set the record in 1967 with a 49-point rout of Wyoming. The five most lopsided games in history all occurred before 1972.