Doug McDermott scored 27 points, Gregory Echenique had 12 points and 12 rebounds, and No. 16 Creighton pulled away in the second half for a 64-42 victory over Nebraska in the annual meeting of the state rivals Thursday night.
Creighton (8-1) won in Lincoln for the first time since 2004.
Dylan Talley scored 14 points and Brandon Ubel had eight points and 10 rebounds to lead the Cornhuskers (6-2).
Grant Gibbs had 10 assists for Creighton.
Creighton and Nebraska were meeting for the 46th time, and the home team had won the last seven games. The Huskers lead the series 25-21.
The crowd of 13,368 was the first sellout at the Devaney Center since the 2011 game against Kansas and first for a nonconference game since Creighton visited in 2006.