Gusty winds could still make travel difficult on the Colorado's far Eastern Plains.
The National Weather Service says snow in the area should taper off Friday morning but that gusts of up to 50 mph will keep blowing the snow around and reduce visibility.
Some highways, however, have begun to reopen. The eastern half of Interstate 70 has been reopened in both directions between the Denver area and Kansas.
Interstate 76 between Denver and Nebraska is also open again.
In northern Colorado, northbound Interstate 25 from Wellington to Wyoming is closed.
Snowfall has ended but highway traffic remains at a standstill across southeast Wyoming.
The reason is gusty winds that are blowing snow over the roads.
Nearly every major interstate and highway in southeast Wyoming remained closed Friday morning. That includes I-80 east of Rawlins, I-80 from the Cheyenne area to Laramie, and I-25 from the Colorado line to the Wheatland area.
A winter weather advisory remains in effect for southeast Wyoming and western Nebraska. The National Weather Service says gusts of 40 mph or more will reduce visibility to near zero.
The snowstorm that began Tuesday night dumped about a foot of snow on the Cheyenne area.