NASA's youngest shuttle departed Kennedy Space Center at sunrise Wednesday on the first leg of its flight to California. It's bolted to the top of a jumbo jet.
Hundreds gathered at the runway to bid Endeavour farewell, following two days of rain delays.
Endeavour will make it as far as Houston on Wednesday, after flying low over NASA facilities along the way.
The shuttle will arrive at Los Angeles International Airport on Friday. In mid-October, it will be transported down city streets to the California Science Center.
This is NASA's last ferry flight of a shuttle. Atlantis will remain at Kennedy for display. Discovery is already at the Smithsonian Institution.
Endeavour flew 25 times in space before retiring last year.