NASA's youngest shuttle was supposed to depart Florida's Kennedy Space Center on Monday for its permanent museum home in Los Angeles. But stormy weather along the Gulf of Mexico nixed the travel plans until Wednesday morning.
The shuttle will be bolted to the top of a modified jumbo jet when it leaves Florida.
Endeavour will stop off in Houston, home to Mission Control, and fly low over NASA facilities en route. After a stop at Edwards Air Force Base in California, it will arrive at Los Angeles International Airport on Friday, a day later than planned.
Endeavour, which retired last year, will go on display at the California Science Center.